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Recent Publications

Cell-Oct13

"Fifteen Years Later: Hard and Soft Selection Sweeps Confirm a Large Population Number for HIV In Vivo."

PLOS Genetics, 2014

Cell-Oct13

"Stochastic Fate Selection in HIV-Infected Patients."

Cell, 2013

Rouzine13A"Design Requirements for Interfering Particles To Maintain Coadaptive Stability with HIV-1."

Journal of Virology, 2013

"CC02013BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism."

Cell Cycle, 2013

cell2012graphicLSW"An Endogenous Accelerator for Viral Gene Expression Confers a Fitness Advantage"

Cell, 2012

PNAS2012-L"Transcriptional burst frequency and burst size are equally modulated across the human genome."

Proceedings of the National Academy of Sciences, 2012.

"Dynamics of protein noise can distinguish between alternate sources of gene-expression variability."

Molecular Systems Biology, 2012.

The Laboratory for Quantitative and Synthetic Virology

Our lab is interested in understanding the fundamental principles of gene regulatory circuits and how viral 'master circuits' exploit these principles to control virus replication. Ultimately, our goal is to exploit these circuitry principles to engineer the next generation of antiviral therapies.

The lab employs a coupled computational experimental approach that relies on quantitative time-lapse fluorescence microscopy with mathematical modeling to study viral gene expression circuits and expression 'noise' at the single-cell level.

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A 12-hour microscopy movie of human T cells infected with an HIV virus engineered to express red and green fluorescent proteins at different stages of infection. These movies enable us to analyze viral circuitry to identify weak points that can be exploited by novel therapies.
 

nih_new_innovator

National Institute of General Medical Sciences

HINT (NIAID) HIV Immune Networks Team

Alfred P Sloan Foundation

NSF

Bill & Melinda Gates Foundation

W. M. Keck Foundation

Califorani HIV/AIDS Research Program

Weinberger Lab
Gladstone Institute of Virology and Immunology
University of California, San Francisco
1650 Owens Street, San Francisco, CA 94158.
Phone: (415) 734-4857