CIVIR is a collaborative center that provides infrastructure and training to promote research in investigating the interactions between the immune, vascular and nervous systems in disease in the living animal.
The ability to repeatedly find and reimage a specific area in the living brain is critical for studying onset and progression of pathogenic mechanisms in real time that is particularly important for understanding mechanisms of neurological disease.
Given that the neurovascular and gliovascular interfaces determine a variety of physiological functions of the nervous system, CIVIR is involved in the study of:
- Vascular effects, glial cell activation and axonal damage
- BBB disruption
- Peripheral cell recruitment into the CNS
- Microglial activation
- Neuronal activity
- Molecular probe development
- Multiple sclerosis, stroke, and Alzheimer's disease animal models
- Testing new therapeutics for neurologic diseases
In addition, imaging techniques developed at the CIVIR can be applied to:
- Nervous system tumors
- Stem cells after transplantation
- Imaging vascular abnormalities and inflammation in a wide range of neurologic diseases, such as HIV encephalitis, spinal cord injury, CNS infection, and pain
- Detection of molecular probes in the CNS