Gladstone Institutes scientist Nevan Krogan, PhD, today is announcing research that identifies how HIV—the virus that causes AIDS—hijacks the body’s own defenses to promote infection. This discovery could one day help curb the spread of the HIV/AIDS pandemic.
Scientists at the Gladstone Institutes have discovered new protein fragments in semen that enhance the ability of HIV, the virus that causes AIDS, to infect new cells—a discovery that one day could help curb the global spread of this deadly pathogen.
A scientist at the Gladstone Institutes has discovered how a gene known as SIRT3 contributes to a suite of health problems sweeping across America, offering new insight into how to combat these potentially fatal conditions.
The Gladstone Institutes will receive funds totaling $5.6 million over five years as part of the first-ever major funding initiative focusing on HIV eradication. The funds will help three principal investigators at Gladstone, an independent biomedical-research organization, to explore the molecular basis for HIV latency where the virus that causes AIDS “hides” dormant within cells waiting for an opportunity to reemerge when therapy is withdrawn.
The Gladstone Institutes has been named America's best place to work in academia, capping a seven-year stint in which readers of The Scientist have ranked the independent biomedical-research organization among academia's top ten places to work.
The Gladstone Institutes, a leading biomedical-research organization, today announced its participation in a bold new consortium intended to help the global community better identify, prevent and treat outbreaks of new or re-emerging viruses.
For the AIDS community, Thanksgiving came a bit early this year, and after many difficult years, three announcements give hope and reason for celebration during this year's World AIDS Day. First, the UNAIDS reported that the pandemic might have crested, and second, two studies from the Gladstone Institutes showed the first evidence that HIV infection can be prevented by drugs and solved a long-standing mystery about how HIV destroys the immune system.
Scientists at Gladstone Institute of Virology and Immunology have solved a long-standing mystery about HIV infection—namely how HIV promotes the death of CD4 T cells. It is the loss of this critical subset of immune cells that leads to the development of AIDS. Most immune cells that die during HIV infection are seemingly not infected, a phenomenon formerly described as “bystander cell killing.” Now the Gladstone scientists report that these “bystander” cells are actually the victims of a failed or abortive form of viral infection. Their findings are published in today's issue of the journal Cell.
In a finding with the potential to fundamentally change strategies to slow the global HIV epidemic, a new study called iPrEx shows that individuals at high risk for HIV infection who took a single daily tablet containing two widely used HIV medications, emtricitabine and tenofovir (FTC/TDF), experienced an average of 43.8% fewer HIV infections than those who received a placebo pill (95% CI 15.4 to 62.6%; P=0.005). The study, reported in the New England Journal of Medicine, is the first evidence that this new HIV prevention method, called pre-exposure prophylaxis or PrEP, reduces HIV infection risk in people.
Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have found that an enzyme associated with the storage of fat in the liver is required for the infectious activity of the hepatitis C virus (HCV). This discovery may offer a new strategy for treating the infection.