Publications

Yadong Huang, MD, PhDKynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. View in: PubMed
Yadong Huang, MD, PhDHuang Y. Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases. Curr Opin Lipidol. 2010 Aug; 21(4):337-45. View in: PubMed
Yadong Huang, MD, PhDStructure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. View in: PubMed
Yadong Huang, MD, PhDButtini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol. 2010 Aug; 177(2):563-9. View in: PubMed
Yadong Huang, MD, PhDC-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. View in: PubMed
Yadong Huang, MD, PhDHuang Y. Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease. Trends Mol Med. 2010 Jun; 16(6):287-94. View in: PubMed
Yadong Huang, MD, PhDApolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. View in: PubMed
Yadong Huang, MD, PhDLi G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell. 2009 Dec 4; 5(6):634-45. View in: PubMed
Yadong Huang, MD, PhDApolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. View in: PubMed
Yadong Huang, MD, PhDTesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T. Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. J Neurochem. 2009 Aug; 110(4):1254-62. View in: PubMed