Publications

Yadong Huang, MD, PhDApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. View in: PubMed
Yadong Huang, MD, PhDHuang Y. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. Biochem Soc Trans. 2011 Aug; 39(4):924-32. View in: PubMed
Yadong Huang, MD, PhDReducing human apolipoprotein e levels attenuates age-dependent aß accumulation in mutant human amyloid precursor protein transgenic mice. View in: PubMed
Yadong Huang, MD, PhDZwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 2011 Jun 10; 145(6):863-74. View in: PubMed
Yadong Huang, MD, PhDBrodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13; 286(19):17217-26. View in: PubMed
Yadong Huang, MD, PhDBien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci U S A. 2011 Mar 8; 108(10):4236-41. View in: PubMed
Yadong Huang, MD, PhDSmall molecule structure correctors abolish detrimental effects of apolipoprotein e4 in cultured neurons. View in: PubMed
Yadong Huang, MD, PhDChen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem. 2011 Feb 18; 286(7):5215-21. View in: PubMed
Yadong Huang, MD, PhDRoles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. View in: PubMed
Yadong Huang, MD, PhDAndrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010 Oct 13; 30(41):13707-17. View in: PubMed