Cardiovascular Disease

Cardiovascular disease—including heart attacks, congenital heart defects and many other disorders—is the world’s leading cause of death. Heart failure alone afflicts more than 23 million around the world.

Regenerating Hearts at Gladstone

Nobel at GladstoneIn the three decades that Gladstone has worked to overcome cardiovascular disease, our scientists have made significant progress against this devastating illness. We’ve conducted foundational research into the metabolism of cholesterol, for example, contributing to today’s understanding of how cholesterol and heart disease are linked—and how to use that information to prevent adult heart disease. We have mapped out molecules that direct the development of fetal hearts—unraveling how nature tells a cell to become a heart cell. This has profoundly changed our understanding of congenital heart defects—leading to Gladstone investigators’ discovery of genetic causes of heart disease and paving the way to future prevention.

And in the past several years, much of our work has expanded on the revolutionary discovery from Shinya Yamanaka, MD, PhD, who is formerly a Gladstone postdoctoral fellow and currently a Gladstone senior investigator. Dr. Yamanaka’s discovery—of how to transform ordinary adult skin cells into stem cells that, like embryonic stem cells, are capable of developing into any cell in the human body—has fundamentally altered the fields of developmental biology and stem cell research. For Gladstone cardiovascular research, we see this promising technology in two main areas: Dr. Yamanaka’s induced pluripotent stem cell, or iPS, technology shows amazing promise for the future of regenerating damaged hearts—and the modeling of disease as a way to better discover and test new therapies in the laboratory.

Thanks to iPS technology, for example, we can run drug tests on heart cells created from a patient’s own skin cells—cells that contain a complete set of the genes that resulted in the disease. In the area of regenerative medicine, Gladstone scientists have already transformed skin cells into beating heart cells in a petri dish. Just recently our researchers demonstrated how to make non-muscle cells convert directly into new muscle to repair damage in the hearts of live animals.

Certainly, the need for such breakthroughs is urgent. So we are working with purpose and focus on transforming such game-changing research into therapies that help doctors restore hearts damaged by heart attacks and disease.

A key part of our work at Gladstone is training tomorrow’s cardiovascular physicians and researchers. Our faculty are professors at the University of California, San Francisco (UCSF). They train our curious, passionate and determined graduate students, medical students and postdoctoral fellows—showing them how to approach complex problems from multiple points of entry. To learn more about training at Gladstone, please visit the Training Programs section of our website.

Featured Publications

Benoit Bruneau PhD et al (2012) Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage. Cell September 13; 151(1):206-220. View in: PubMed
Deepak Srivastava MD et al (2012) MicroRNA-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting Vascular Endothelial Growth Factor Signaling. Circ Res. Nov 9; 111(11):1421-33. View in: PubMed