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Blood. 2012 Aug 9; 120(6):1299-308. http://www.ncbi.nlm.nih.gov/pubmed/22723549 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Fujishiro SH, Nakano K, Mizukami Y, Azami T, Arai Y, Matsunari H, Ishino R, Nishimura T, Watanabe M, Abe T, Furukawa Y, Umeyama K, Yamanaka S, Ema M, Nagashima H, Hanazono Y. Generation of Naive-like Porcine Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development. Stem Cells Dev. 2012 Aug 13. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22889279 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Blanpain C, Daley GQ, Hochedlinger K, Passegue E, Rossant J, Yamanaka S. (2012) Stem cells assessed. Nat Rev Mol Cell Biol 13: 471-6. http://www.ncbi.nlm.nih.gov/pubmed/22678486 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Isobe H, Shoji M, Yamanaka S, Umena Y, Kawakami K, Kamiya N, Shen JR, Yamaguchi K. (2012) Theoretical illumination of water-inserted structures of the CaMn4O5 cluster in the S2 and S3 states of oxygen-evolving complex of photosystem II: full geometry optimizations by B3LYP hybrid density functional. Dalton Trans 41: 13727-40. http://www.ncbi.nlm.nih.gov/pubmed/23037319 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tateishi K, Tateishi U, Sato M, Yamanaka S, Kanno H, Murata H, Inoue T, Kawahara N. (2012) Application of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET Imaging to Predict Highly Malignant Tumor Grades and Hypoxia-Inducible Factor-1alpha Expression in Patients with Glioma. AJNR Am J Neuroradiol http://www.ncbi.nlm.nih.gov/pubmed/22700754 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yoshida Y, Yamanaka S. (2012) An emerging strategy of gene therapy for cardiac disease. Circ Res 111: 1108-10 http://www.ncbi.nlm.nih.gov/pubmed/23065338 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Kobayashi Y, Okada Y, Itakura G, Iwai H, Nishimura S, Yasuda A, Nori S, Hikishima K, Konomi T, Fujiyoshi K, Tsuji O, Toyama Y, Yamanaka S, Nakamura M, Okano H. (2012) Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity. PLoS One 7: e52787. http://www.ncbi.nlm.nih.gov/pubmed/23300777 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S. (2012) An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells http://www.ncbi.nlm.nih.gov/pubmed/23193063 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tanaka K, Isobe H, Yamanaka S, Yamaguchi K. (2012) Similarities of artificial photosystems by ruthenium oxo complexes and native water splitting systems. Proc Natl Acad Sci U S A 109: 15600-5. http://www.ncbi.nlm.nih.gov/pubmed/22761310 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamana R, Iwasaki M, Wakabayashi M, Nakagawa M, Yamanaka S, Ishihama Y. (2012) Rapid and Deep Profiling of Human Induced Pluripotent Stem Cell Proteome by One-shot NanoLC-MS/MS Analysis with Meter-scale Monolithic Silica Columns. J Proteome Res http://www.ncbi.nlm.nih.gov/pubmed/23210603 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yoshida Y, Yamanaka S. (2012) Labor pains of new technology: direct cardiac reprogramming. Circ Res 111: 3-4 http://www.ncbi.nlm.nih.gov/pubmed/22723216 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Watanabe A, Yamada Y, Yamanaka S. (2013) Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci 368: 20120292. http://www.ncbi.nlm.nih.gov/pubmed/23166402 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamana R, Iwasaki M, Wakabayashi M, Nakagawa M, Yamanaka S, Ishihama Y. (2013) Rapid and Deep Profiling of Human Induced Pluripotent Stem Cell Proteome by One-shot NanoLC-MS/MS Analysis with Meter-scale Monolithic Silica Columns. J Proteome Res 12: 214-21. http://www.ncbi.nlm.nih.gov/pubmed/23210603 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H. Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells. Sci Transl Med. 2012 Aug 1; 4(145):145ra104. http://www.ncbi.nlm.nih.gov/pubmed/22855461 1 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K (2013) Steps toward safe cell therapy using induced pluripotent stem cells.Circ Res. 2013 Feb 1;112(3):523-33. doi: 10.1161/CIRCRESAHA.111.256149 http://www.ncbi.nlm.nih.gov/pubmed/23371901 1 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Kajiwara M, Aoi T, Okita K, Takahashi R, Inoue H, Takayama N, Endo H, Eto K, Toguchida J, Uemoto S, Yamanaka S. Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12538-43. http://www.ncbi.nlm.nih.gov/pubmed/22802639 2 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K (2013) Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun. 2013 Jan 22;4:1367. doi: 10.1038/ncomms2378 http://www.ncbi.nlm.nih.gov/pubmed/23340407 2 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S. Derivation conditions impact x-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell. 2012 Jul 6; 11(1):91-9. http://www.ncbi.nlm.nih.gov/pubmed/22770243 3 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Rapid and Deep Profiling of Human Induced Pluripotent Stem Cell Proteome by One-shot NanoLC-MS/MS Analysis with Meter-scale Monolithic Silica Columns. http://www.ncbi.nlm.nih.gov/pubmed/23210603 3 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development. http://www.ncbi.nlm.nih.gov/pubmed/22889279 4 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells. http://www.ncbi.nlm.nih.gov/pubmed/22855461 5 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hayashi Y, Saitou M, Yamanaka S. Germline development from human pluripotent stem cells toward disease modeling of infertility. Fertil Steril. 2012 Jun; 97(6):1250-9. http://www.ncbi.nlm.nih.gov/pubmed/22656305 6 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/22802639 6 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Sakurai H, Yamanaka S. [Research for cell therapy by induced pluripotent stem cell]. Nihon Rinsho. 2011 Dec; 69(12):2114-8. http://www.ncbi.nlm.nih.gov/pubmed/22242307 7 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Derivation conditions impact x-inactivation status in female human induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/22770243 7 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol. 2011; 29(12):1132-44. http://www.ncbi.nlm.nih.gov/pubmed/22119741 8 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. http://www.ncbi.nlm.nih.gov/pubmed/22723549 8 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech. 2012 Mar; 5(2):220-30. http://www.ncbi.nlm.nih.gov/pubmed/22052944 9 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induced pluripotent stem cells: past, present, and future. http://www.ncbi.nlm.nih.gov/pubmed/22704507 9 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S, Oshimura M. Integration-free iPS cells engineered using human artificial chromosome vectors. PLoS One. 2011; 6(10):e25961. http://www.ncbi.nlm.nih.gov/pubmed/21998730 10 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Stem cells assessed. http://www.ncbi.nlm.nih.gov/pubmed/22678486 10 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H. Anti-Aß drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One. 2011; 6(9):e25788. http://www.ncbi.nlm.nih.gov/pubmed/21984949 11 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Germline development from human pluripotent stem cells toward disease modeling of infertility. http://www.ncbi.nlm.nih.gov/pubmed/22656305 11 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H. Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl Acad Sci U S A. 2011 Oct 4; 108(40):16825-30. http://www.ncbi.nlm.nih.gov/pubmed/21949375 12 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Miki K, Uenaka H, Saito A, Miyagawa S, Sakaguchi T, Higuchi T, Shimizu T, Okano T, Yamanaka S, Sawa Y. (2012) Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats. Stem Cells Transl Med 1: 430-7. http://www.ncbi.nlm.nih.gov/pubmed/23197822 12 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Nagata N, Yamanaka S. Immunogenicity of induced pluripotent stem cells. Circ Res. 2011 Sep 16; 109(7):720-1. http://www.ncbi.nlm.nih.gov/pubmed/21921270 13 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka [Research for cell therapy by induced pluripotent stem cell]. http://www.ncbi.nlm.nih.gov/pubmed/22242307 13 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Yoshizaki T, Yamanaka S, Okano H, Suzuki N. Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum Mol Genet. 2011 Dec 1; 20(23):4530-9. http://www.ncbi.nlm.nih.gov/pubmed/21900357 14 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. http://www.ncbi.nlm.nih.gov/pubmed/22119741 14 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent LC, Yamanaka S, Loring JF. Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. Cell Res. 2011 Nov; 21(11):1551-63. http://www.ncbi.nlm.nih.gov/pubmed/21894191 15 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech. 2012 Mar;5(2):220-30. doi: 10.1242/dmm.008409. Epub 2011 Nov 3 http://www.ncbi.nlm.nih.gov/pubmed/22052944 15 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nakamura T, Nakagawa M, Ichisaka T, Shiota A, Yamanaka S. Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol. 2011 Nov; 31(21):4366-78. http://www.ncbi.nlm.nih.gov/pubmed/21896782 16 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Integration-free iPS cells engineered using human artificial chromosome vectors. http://www.ncbi.nlm.nih.gov/pubmed/21998730 16 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Uosaki H, Fukushima H, Takeuchi A, Matsuoka S, Nakatsuji N, Yamanaka S, Yamashita JK. Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLoS One. 2011; 6(8):e23657. http://www.ncbi.nlm.nih.gov/pubmed/21876760 17 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Anti-Aß drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. http://www.ncbi.nlm.nih.gov/pubmed/21984949 17 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Yamanaka S. Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12; 366(1575):2198-207. http://www.ncbi.nlm.nih.gov/pubmed/21727125 18 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. http://www.ncbi.nlm.nih.gov/pubmed/21949375 18 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Higashi H, Brüstle O, Daley GQ, Yamanaka S. The nomenclature system should be sustainable, but also practical. Cell Stem Cell. 2011 Jun 3; 8(6):606-7. http://www.ncbi.nlm.nih.gov/pubmed/21624802 19 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Immunogenicity of induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/21921270 19 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S. ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency. PLoS One. 2011; 6(5):e20461. http://www.ncbi.nlm.nih.gov/pubmed/21637830 20 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Modeling familial Alzheimer's disease with induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/21900357 20 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 May; 8(5):409-12. http://www.ncbi.nlm.nih.gov/pubmed/21460823 21 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. http://www.ncbi.nlm.nih.gov/pubmed/21894191 21 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK. Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One. 2011; 6(2):e16734. http://www.ncbi.nlm.nih.gov/pubmed/21364991 22 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Essential roles of ECAT15-2/Dppa2 in functional lung development. http://www.ncbi.nlm.nih.gov/pubmed/21896782 22 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y. Generation of human melanocytes from induced pluripotent stem cells. PLoS One. 2011; 6(1):e16182. http://www.ncbi.nlm.nih.gov/pubmed/21249204 23 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. http://www.ncbi.nlm.nih.gov/pubmed/21876760 23 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med. 2010 Dec 20; 207(13):2817-30. http://www.ncbi.nlm.nih.gov/pubmed/21098095 24 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induced pluripotent stem cells: opportunities and challenges. http://www.ncbi.nlm.nih.gov/pubmed/21727125 24 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yoshida Y, Yamanaka S. iPS cells: a source of cardiac regeneration. J Mol Cell Cardiol. 2011 Feb; 50(2):327-32. http://www.ncbi.nlm.nih.gov/pubmed/21040726 25 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka The nomenclature system should be sustainable, but also practical. http://www.ncbi.nlm.nih.gov/pubmed/21624802 25 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Egusa H, Okita K, Kayashima H, Yu G, Fukuyasu S, Saeki M, Matsumoto T, Yamanaka S, Yatani H. Gingival fibroblasts as a promising source of induced pluripotent stem cells. PLoS One. 2010; 5(9):e12743. http://www.ncbi.nlm.nih.gov/pubmed/20856871 26 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency. http://www.ncbi.nlm.nih.gov/pubmed/21637830 26 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Imamura M, Aoi T, Tokumasu A, Mise N, Abe K, Yamanaka S, Noce T. Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes. Mol Reprod Dev. 2010 Sep; 77(9):802-11. http://www.ncbi.nlm.nih.gov/pubmed/20722049 27 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka A more efficient method to generate integration-free human iPS cells. http://www.ncbi.nlm.nih.gov/pubmed/21460823 27 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep 1; 120(9):3120-6. http://www.ncbi.nlm.nih.gov/pubmed/20739754 28 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. http://www.ncbi.nlm.nih.gov/pubmed/21364991 28 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nakagawa M, Takizawa N, Narita M, Ichisaka T, Yamanaka S. Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14152-7. http://www.ncbi.nlm.nih.gov/pubmed/20660764 29 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of human melanocytes from induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/21249204 29 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yoshida Y, Yamanaka S. Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration. Circulation. 2010 Jul 6; 122(1):80-7. http://www.ncbi.nlm.nih.gov/pubmed/20606130 30 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/21098095 30 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S, Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuzaki M, Ikeda E, Toyama Y, Nakamura M, Yamanaka S, Okano H. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12704-9. http://www.ncbi.nlm.nih.gov/pubmed/20615974 31 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Derivation of Engraftable Myogenic Precursors from Murine ES/iPS cells and Generation of Disease-specific iPS cells from Patients with Duchenne Muscular dystrophy (DMD) and Other Diseases. http://www.ncbi.nlm.nih.gov/pubmed/21921492 31 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S. Patient-specific pluripotent stem cells become even more accessible. Cell Stem Cell. 2010 Jul 2; 7(1):1-2. http://www.ncbi.nlm.nih.gov/pubmed/20621038 32 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka iPS cells: a source of cardiac regeneration. http://www.ncbi.nlm.nih.gov/pubmed/21040726 32 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY). 2010 Jul; 2(7):415-31. http://www.ncbi.nlm.nih.gov/pubmed/20634564 33 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Gingival fibroblasts as a promising source of induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/20856871 33 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T. Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. Cardiovasc Res. 2010 Nov 1; 88(2):314-23. http://www.ncbi.nlm.nih.gov/pubmed/20547733 34 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes. http://www.ncbi.nlm.nih.gov/pubmed/20722049 34 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K. Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells. Genes Cells. 2010 Jun; 15(6):607-18. http://www.ncbi.nlm.nih.gov/pubmed/20477876 35 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. http://www.ncbi.nlm.nih.gov/pubmed/20739754 35 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Yamanaka S. Induction of pluripotency by defined factors. Exp Cell Res. 2010 Oct 1; 316(16):2565-70. http://www.ncbi.nlm.nih.gov/pubmed/20420827 36 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Promotion of direct reprogramming by transformation-deficient Myc. http://www.ncbi.nlm.nih.gov/pubmed/20660764 36 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K. Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells. Atherosclerosis. 2010 Sep; 212(1):42-7. http://www.ncbi.nlm.nih.gov/pubmed/20488443 37 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. http://www.ncbi.nlm.nih.gov/pubmed/20615974 37 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukada S, Yamamoto H, Yamanaka S, Nakahata T, Heike T. Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. FASEB J. 2010 Jul; 24(7):2245-53. http://www.ncbi.nlm.nih.gov/pubmed/20181939 38 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration. http://www.ncbi.nlm.nih.gov/pubmed/20606130 38 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Hong H, Takahashi K, Yamanaka S. Generation of mouse-induced pluripotent stem cells with plasmid vectors. Nat Protoc. 2010; 5(3):418-28. http://www.ncbi.nlm.nih.gov/pubmed/20203661 39 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Patient-specific pluripotent stem cells become even more accessible. http://www.ncbi.nlm.nih.gov/pubmed/20621038 39 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nakagawa M, Yamanaka S. Reprogramming of somatic cells to pluripotency. 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Mol Ther. 2010 Feb; 18(2):386-93. http://www.ncbi.nlm.nih.gov/pubmed/19997091 41 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. http://www.ncbi.nlm.nih.gov/pubmed/20547733 41 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Narita M, Yokura M, Ichisaka T, Yamanaka S. Human induced pluripotent stem cells on autologous feeders. PLoS One. 2009; 4(12):e8067. http://www.ncbi.nlm.nih.gov/pubmed/19956543 42 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/20477876 42 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nagata S, Toyoda M, Yamaguchi S, Hirano K, Makino H, Nishino K, Miyagawa Y, Okita H, Kiyokawa N, Nakagawa M, Yamanaka S, Akutsu H, Umezawa A, Tada T. Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells. Genes Cells. 2009 Dec; 14(12):1395-404. http://www.ncbi.nlm.nih.gov/pubmed/19912344 43 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction of pluripotency by defined factors. http://www.ncbi.nlm.nih.gov/pubmed/20420827 43 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nakamura K, Salomonis N, Tomoda K, Yamanaka S, Conklin BR. G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies. PLoS One. 2009; 4(11):e7780. http://www.ncbi.nlm.nih.gov/pubmed/19936228 44 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells. http://www.ncbi.nlm.nih.gov/pubmed/20488443 44 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Niwa A, Umeda K, Chang H, Saito M, Okita K, Takahashi K, Nakagawa M, Yamanaka S, Nakahata T, Heike T. Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors. J Cell Physiol. 2009 Nov; 221(2):367-77. http://www.ncbi.nlm.nih.gov/pubmed/19562687 45 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/20181939 45 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S. Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat Rev Genet. 2009 Dec; 10(12):878-83. http://www.ncbi.nlm.nih.gov/pubmed/19859062 46 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of mouse-induced pluripotent stem cells with plasmid vectors. http://www.ncbi.nlm.nih.gov/pubmed/20203661 46 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S. Ekiden to iPS Cells. Nat Med. 2009 Oct; 15(10):1145-8. http://www.ncbi.nlm.nih.gov/pubmed/19812575 47 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Reprogramming of somatic cells to pluripotency. http://www.ncbi.nlm.nih.gov/pubmed/21222208 47 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nishimura K, Nakagawa T, Ono K, Ogita H, Sakamoto T, Yamamoto N, Okita K, Yamanaka S, Ito J. Transplantation of mouse induced pluripotent stem cells into the cochlea. Neuroreport. 2009 Sep 23; 20(14):1250-4. http://www.ncbi.nlm.nih.gov/pubmed/19625987 48 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Complete genetic correction of ips cells from Duchenne muscular dystrophy. http://www.ncbi.nlm.nih.gov/pubmed/19997091 48 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S. Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell. 2009 Sep 4; 5(3):237-41. http://www.ncbi.nlm.nih.gov/pubmed/19716359 49 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Human induced pluripotent stem cells on autologous feeders. http://www.ncbi.nlm.nih.gov/pubmed/19956543 49 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Silva J, Nichols J, Theunissen TW, Guo G, van Oosten AL, Barrandon O, Wray J, Yamanaka S, Chambers I, Smith A. Nanog is the gateway to the pluripotent ground state. Cell. 2009 Aug 21; 138(4):722-37. http://www.ncbi.nlm.nih.gov/pubmed/19703398 50 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19912344 50 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature. 2009 Aug 27; 460(7259):1132-5. http://www.ncbi.nlm.nih.gov/pubmed/19668191 51 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies. http://www.ncbi.nlm.nih.gov/pubmed/19936228 51 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yokoo N, Baba S, Kaichi S, Niwa A, Mima T, Doi H, Yamanaka S, Nakahata T, Heike T. The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells. Biochem Biophys Res Commun. 2009 Sep 25; 387(3):482-8. http://www.ncbi.nlm.nih.gov/pubmed/19615974 52 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors. http://www.ncbi.nlm.nih.gov/pubmed/19562687 52 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H, Yamanaka S. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol. 2009 Aug; 27(8):743-5. http://www.ncbi.nlm.nih.gov/pubmed/19590502 53 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induced pluripotent stem cells and reprogramming: seeing the science through the hype. http://www.ncbi.nlm.nih.gov/pubmed/19859062 53 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S. Elite and stochastic models for induced pluripotent stem cell generation. Nature. 2009 Jul 2; 460(7251):49-52. http://www.ncbi.nlm.nih.gov/pubmed/19571877 54 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Ekiden to iPS Cells. http://www.ncbi.nlm.nih.gov/pubmed/19812575 54 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Ohnuki M, Takahashi K, Yamanaka S. Generation and characterization of human induced pluripotent stem cells. Curr Protoc Stem Cell Biol. 2009 Jun; Chapter 4:Unit 4A.2. http://www.ncbi.nlm.nih.gov/pubmed/19536759 55 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Transplantation of mouse induced pluripotent stem cells into the cochlea. http://www.ncbi.nlm.nih.gov/pubmed/19625987 55 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tanaka T, Tohyama S, Murata M, Nomura F, Kaneko T, Chen H, Hattori F, Egashira T, Seki T, Ohno Y, Koshimizu U, Yuasa S, Ogawa S, Yamanaka S, Yasuda K, Fukuda K. In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun. 2009 Aug 7; 385(4):497-502. http://www.ncbi.nlm.nih.gov/pubmed/19464263 56 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hypoxia enhances the generation of induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19716359 56 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tsubooka N, Ichisaka T, Okita K, Takahashi K, Nakagawa M, Yamanaka S. Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts. Genes Cells. 2009 Jun; 14(6):683-94. http://www.ncbi.nlm.nih.gov/pubmed/19476507 57 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nanog is the gateway to the pluripotent ground state. http://www.ncbi.nlm.nih.gov/pubmed/19703398 57 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Taura D, Sone M, Homma K, Oyamada N, Takahashi K, Tamura N, Yamanaka S, Nakao K. Induction and isolation of vascular cells from human induced pluripotent stem cells--brief report. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1100-3. http://www.ncbi.nlm.nih.gov/pubmed/19423866 58 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. http://www.ncbi.nlm.nih.gov/pubmed/19668191 58 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Senju S, Haruta M, Matsunaga Y, Fukushima S, Ikeda T, Takahashi K, Okita K, Yamanaka S, Nishimura Y. Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells. Stem Cells. 2009 May; 27(5):1021-31. http://www.ncbi.nlm.nih.gov/pubmed/19415766 59 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19615974 59 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, Ikeda H, Yoshimura N, Takahashi M. Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett. 2009 Jul 24; 458(3):126-31. http://www.ncbi.nlm.nih.gov/pubmed/19379795 60 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Variation in the safety of induced pluripotent stem cell lines. http://www.ncbi.nlm.nih.gov/pubmed/19590502 60 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Daley GQ, Lensch MW, Jaenisch R, Meissner A, Plath K, Yamanaka S. Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell. 2009 Mar 6; 4(3):200-1; author reply 202. http://www.ncbi.nlm.nih.gov/pubmed/19265657 61 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Elite and stochastic models for induced pluripotent stem cell generation. http://www.ncbi.nlm.nih.gov/pubmed/19571877 61 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Taura D, Noguchi M, Sone M, Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, Nakatsuji N, Okano H, Yamanaka S, Nakao K. Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS Lett. 2009 Mar 18; 583(6):1029-33. http://www.ncbi.nlm.nih.gov/pubmed/19250937 62 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation and characterization of human induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19536759 62 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tanaka Y, Ikeda T, Kishi Y, Masuda S, Shibata H, Takeuchi K, Komura M, Iwanaka T, Muramatsu S, Kondo Y, Takahashi K, Yamanaka S, Hanazono Y. ERas is expressed in primate embryonic stem cells but not related to tumorigenesis. Cell Transplant. 2009; 18(4):381-9. http://www.ncbi.nlm.nih.gov/pubmed/19622226 63 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes. http://www.ncbi.nlm.nih.gov/pubmed/19464263 63 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Aiba K, Nedorezov T, Piao Y, Nishiyama A, Matoba R, Sharova LV, Sharov AA, Yamanaka S, Niwa H, Ko MS. Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells. DNA Res. 2009 Feb; 16(1):73-80. http://www.ncbi.nlm.nih.gov/pubmed/19112179 64 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts. http://www.ncbi.nlm.nih.gov/pubmed/19476507 64 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science. 2008 Nov 7; 322(5903):949-53. http://www.ncbi.nlm.nih.gov/pubmed/18845712 65 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction and isolation of vascular cells from human induced pluripotent stem cells--brief report. http://www.ncbi.nlm.nih.gov/pubmed/19423866 65 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Narazaki G, Uosaki H, Teranishi M, Okita K, Kim B, Matsuoka S, Yamanaka S, Yamashita JK. Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation. 2008 Jul 29; 118(5):498-506. http://www.ncbi.nlm.nih.gov/pubmed/18625891 66 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19415766 66 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Aoi T, Yae K, Nakagawa M, Ichisaka T, Okita K, Takahashi K, Chiba T, Yamanaka S. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science. 2008 Aug 1; 321(5889):699-702. http://www.ncbi.nlm.nih.gov/pubmed/18276851 67 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of retinal cells from mouse and human induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19379795 67 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30; 131(5):861-72. http://www.ncbi.nlm.nih.gov/pubmed/18035408 68 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Broader implications of defining standards for the pluripotency of iPSCs. http://www.ncbi.nlm.nih.gov/pubmed/19265657 68 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2008 Jan; 26(1):101-6. http://www.ncbi.nlm.nih.gov/pubmed/18059259 69 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19250937 69 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S. New advances in iPS cell research do not obviate the need for human embryonic stem cells. Cell Stem Cell. 2007 Oct 11; 1(4):367-8. http://www.ncbi.nlm.nih.gov/pubmed/18371375 70 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka ERas is expressed in primate embryonic stem cells but not related to tumorigenesis. http://www.ncbi.nlm.nih.gov/pubmed/19622226 70 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell. 2007 Jun 7; 1(1):39-49. http://www.ncbi.nlm.nih.gov/pubmed/18371333 71 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/19112179 71 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature. 2007 Jul 19; 448(7151):313-7. http://www.ncbi.nlm.nih.gov/pubmed/17554338 72 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of mouse induced pluripotent stem cells without viral vectors. http://www.ncbi.nlm.nih.gov/pubmed/18845712 72 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc. 2007; 2(12):3081-9. http://www.ncbi.nlm.nih.gov/pubmed/18079707 73 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/18625891 73 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S, Takahashi K. [Induction of pluripotent stem cells from mouse fibroblast cultures]. Tanpakushitsu Kakusan Koso. 2006 Dec; 51(15):2346-51. http://www.ncbi.nlm.nih.gov/pubmed/17154061 74 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of pluripotent stem cells from adult mouse liver and stomach cells. http://www.ncbi.nlm.nih.gov/pubmed/18276851 74 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25; 126(4):663-76. http://www.ncbi.nlm.nih.gov/pubmed/16904174 75 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction of pluripotent stem cells from adult human fibroblasts by defined factors. http://www.ncbi.nlm.nih.gov/pubmed/18035408 75 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S. Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC Dev Biol. 2006; 6:34. http://www.ncbi.nlm.nih.gov/pubmed/16859545 76 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. http://www.ncbi.nlm.nih.gov/pubmed/18059259 76 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Amano H, Itakura K, Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S. Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Dev Biol. 2006; 6:11. http://www.ncbi.nlm.nih.gov/pubmed/16504174 77 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka New advances in iPS cell research do not obviate the need for human embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/18371375 77 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tokuzawa Y, Maruyama M, Yamanaka S. Utilization of digital differential display to identify novel targets of Oct3/4. Methods Mol Biol. 2006; 329:223-31. http://www.ncbi.nlm.nih.gov/pubmed/16845994 78 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Strategies and new developments in the generation of patient-specific pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/18371333 78 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Ichisaka T, Yamanaka S. Identification of genes involved in tumor-like properties of embryonic stem cells. Methods Mol Biol. 2006; 329:449-58. http://www.ncbi.nlm.nih.gov/pubmed/16846009 79 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Generation of germline-competent induced pluripotent stem cells. http://www.ncbi.nlm.nih.gov/pubmed/17554338 79 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Okita K, Yamanaka S. Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther. 2006 Jan; 1(1):103-11. http://www.ncbi.nlm.nih.gov/pubmed/18220859 80 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction of pluripotent stem cells from fibroblast cultures. http://www.ncbi.nlm.nih.gov/pubmed/18079707 80 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Nakagawa M, Young SG, Yamanaka S. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. J Biol Chem. 2005 Sep 23; 280(38):32768-74. http://www.ncbi.nlm.nih.gov/pubmed/16046393 81 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka [Induction of pluripotent stem cells from mouse fibroblast cultures]. http://www.ncbi.nlm.nih.gov/pubmed/17154061 81 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Nakagawa M, Yamanaka S. [Mechanism for maintaining pluripotency in embryonic stem cells and inner cell mass]. Tanpakushitsu Kakusan Koso. 2005 May; 50(6 Suppl):546-50. http://www.ncbi.nlm.nih.gov/pubmed/15926478 82 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. http://www.ncbi.nlm.nih.gov/pubmed/16904174 82 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S. Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005 Jul 1; 280(26):24371-9. http://www.ncbi.nlm.nih.gov/pubmed/15863505 83 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. http://www.ncbi.nlm.nih.gov/pubmed/16859545 83 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Maruyama M, Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Genomics. 2005 Mar; 85(3):360-71. http://www.ncbi.nlm.nih.gov/pubmed/15718103 84 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). http://www.ncbi.nlm.nih.gov/pubmed/16504174 84 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tomoda K, Yoneda-Kato N, Fukumoto A, Yamanaka S, Kato JY. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004 Oct 8; 279(41):43013-8. http://www.ncbi.nlm.nih.gov/pubmed/15299027 85 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Identification of genes involved in tumor-like properties of embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/16846009 85 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Matsuda E, Shigeoka T, Iida R, Yamanaka S, Kawaichi M, Ishida Y. Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4170-4. http://www.ncbi.nlm.nih.gov/pubmed/15010531 86 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Utilization of digital differential display to identify novel targets of Oct3/4. http://www.ncbi.nlm.nih.gov/pubmed/16845994 86 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30; 113(5):631-42. http://www.ncbi.nlm.nih.gov/pubmed/12787504 87 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Intracellular signaling pathways regulating pluripotency of embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/18220859 87 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature. 2003 May 29; 423(6939):541-5. http://www.ncbi.nlm.nih.gov/pubmed/12774123 88 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. http://www.ncbi.nlm.nih.gov/pubmed/16046393 88 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, Niwa H, Yamanaka S. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003 Apr; 23(8):2699-708. http://www.ncbi.nlm.nih.gov/pubmed/12665572 89 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka [Mechanism for maintaining pluripotency in embryonic stem cells and inner cell mass]. http://www.ncbi.nlm.nih.gov/pubmed/15926478 89 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Qian X, Balestra ME, Yamanaka S, Borén J, Lee I, Innerarity TL. Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. Arterioscler Thromb Vasc Biol. 1998 Jun; 18(6):1013-20. http://www.ncbi.nlm.nih.gov/pubmed/9633945 90 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/15863505 90 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S, Poksay KS, Arnold KS, Innerarity TL. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 1997 Feb 1; 11(3):321-33. http://www.ncbi.nlm.nih.gov/pubmed/9030685 91 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). http://www.ncbi.nlm.nih.gov/pubmed/15718103 91 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S, Poksay KS, Driscoll DM, Innerarity TL. Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif. J Biol Chem. 1996 May 10; 271(19):11506-10. http://www.ncbi.nlm.nih.gov/pubmed/8626710 92 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. http://www.ncbi.nlm.nih.gov/pubmed/15299027 92 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Yamanaka S, Poksay KS, Balestra ME, Zeng GQ, Innerarity TL. Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed. J Biol Chem. 1994 Aug 26; 269(34):21725-34. http://www.ncbi.nlm.nih.gov/pubmed/8063816 93 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis. http://www.ncbi.nlm.nih.gov/pubmed/15010531 93 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. http://www.ncbi.nlm.nih.gov/pubmed/12787504 94 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. http://www.ncbi.nlm.nih.gov/pubmed/12774123 95 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. http://www.ncbi.nlm.nih.gov/pubmed/12665572 96 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. http://www.ncbi.nlm.nih.gov/pubmed/9633945 97 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. http://www.ncbi.nlm.nih.gov/pubmed/9030685 98 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif. http://www.ncbi.nlm.nih.gov/pubmed/8626710 99 Shinya Yamanaka, MD, PhD http://gladstoneinstitutes.org/scientist/yamanaka Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed. http://www.ncbi.nlm.nih.gov/pubmed/8063816 100